Phenobarbital speeds the metabolism of many drugs in dogs, including:However, phenobarbital causes minimal cytochrome P450 enzyme induction in the cat, and therefore these P450-mediated drug interactions are unlikely in the cat.As a tricyclic antidepressant that inhibits norepinephrine reuptake, clomipramine can have pharmacologic interactions with monoamine oxidase inhibitors (which decrease the breakdown of norepinephrine and serotonin): The metabolism of clomipramine can be inhibited by:Table. Side Effects of Aminophylline for Dogs A dog on aminophylline can experience side effects such as vomiting, diarrhea, anxiety or nervousness, insomnia, or increased hunger, thirst and urination.
bloody nose. Epinephrine is commonly called adrenaline and is responsible for the elevated heart rate and "fight or flight" response when your pet is exposed to a stressor or fearful situation. Propranolol may react with these drugs: Drugs that inhibit CYP3A may increase cisapride concentrations and increase the risk of cardiac side effects in humans:Note: in one study in dogs, erythromycin did not alter cisapride pharmacodynamics. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking propranolol: If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. In dogs, enrofloxacin leads to higher theophylline concentrations by about 30-50%.As a dopaminergic (D2) antagonist and prokinetic agent, metoclopramide has several important drug interactions:It has been suggested that metoclopramide may antagonize the effects of dopamine on renal hemodynamics. Abdominal or stomach pain and tenderness. blood in the urine. Do not give your pet two doses at once.Propranolol may react with many drugs.
School of Veterinary Medicine, University of Wisconsin-Madison Side effects may subside with continued therapy or may require dosage adjustments. Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, propranolol can cause side effects in some animals. However:Like ketoconazole, cisapride is a substrate of CYP3A. Ketoconazole is also an inhibitor of p-glycoprotein, an important drug efflux transporter in the gut and biliary tree.
Drug interactions in humans that may also affect dogs and cats.Metronidazole, lidocaine, theophylline, diazepam, propranolol Fluoroquinolones, tetracyclines, erythromycin, theophylline, digoxinCyclosporine, warfarin, digoxin, amitriptyline, midazolam, cisaprideEthanol, aspirin, or acetaminophen overdoses; propofol?Clarithromycin, erythromycin, azole antifungals, fluoxetineGlucocorticoids, clomipramine, lidocaine, theophylline, digoxin, propranolol... World Small Animal Veterinary Association World Congress Proceedings, 2008 bloody stools. Interactions can occur during IV drug administration, during oral absorption, at the target site, or during hepatic or renal elimination, and may lead to loss of efficacy or increased toxicity. During treatment the dog will need to be carefully monitored, both for the r… There is some discussion over it’s effectiveness in treating post-traumatic stress disorders and envenomation.Propranolol blocks the beta1 and beta2 receptors of epinephrine and norepinephrine. Propranolol can be used in the management of an overactive thyroid gland (hyperthyroidism) in cats. In humans, the risk of adverse drug interactions multiplies as the number of administered drugs increases. USE CAUTION WHEN ADMINISTERING THIS DRUG TO DIABETIC PETSUSE CAUTION WHEN ADMINISTERING THIS DRUG TO PETS WITH KIDNEY DISEASE, LIVER DISEASE, OR HEART FAILURE Side effects other than those listed here may also occur. Several drug combinations with furosemide can lead to enhanced toxicity:Other drug combinations with furosemide can affect efficacy:Omeprazole is an inhibitor of some P450s in humans, and may inhibit the metabolism, and possibly increase the toxicity, of: As an inhibitor of gastric acid secretion, omeprazole can also decrease the absorption of:Phenobarbital is a major P450 enzyme inducer in humans and dogs.
Propranolol is a beta blocker that is used to control the heart rate of pets with irregular heart rhythms. Aminophylline dosing information. Top Ten Potential Drug Interactions in Dogs and Cats Note: Do not give your dog theophylline unless it has been recommended by your vet, and always follow the vet’s exact dosing recommendations. Muscle pain or weakness. Cimetidine is a major P450 enzyme inhibitor, and decreases the clearance of many drugs:Until more is known about cimetidine interactions, alternative HAluminum-containing drugs such as sucralfate can form complexes with many other drugs in the GI tract, markedly decreasing drug absorption:This is a physicochemical interaction that is likely to occur in dogs and cats as it does in humans.Ketoconazole and itraconazole are best absorbed at acidic pH; therefore, do not combine these drugs with:Ketoconazole inhibits a cytochrome P450 enzyme (CYP3A), with a wide substrate range and high potential for drug-drug interactions. Drug interactions with aminophylline oral and propranolol oral. High plasma concentrations of cisapride can lead to potentially fatal cardiac arrhythmias in humans. Be sure to notify your veterinarian of your pet’s full medical history and all medications that they are currently taking.
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