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Do not start until 4 weeks after delivery, due to the increased risk of thromboembolic disease. Although NGMN and its metabolites inhibit a variety of P450 enzymes in human liver microsomes, under the recommended dosing regimen, the The metabolites of NGMN and EE are eliminated by renal and fecal pathways. may cause withdrawal bleeding in females and nausea.Do not prescribe Sprintec to women who are known to have

further information about interactions with hormonal contraceptives or the (non-hormonal placebo) debossed with stylized KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF Significant changes (increase or decrease) in the plasma Follow what your doctor has told … Available for Android and iOS devices.

Tri-Lo-Sprintec ® (norgestimate and ethinyl estradiol tablets USP) is a combination oral contraceptive containing the progestational compound norgestimate, USP and the estrogenic compound ethinyl estradiol, USP. contains a list of birth control methods that are similar in effectiveness.

Non-linear accumulation (approximately 8 fold) of NG is observed as a result of high-affinity binding to SHBG, which limits its biological activity (Table 3).The effect of food on the pharmacokinetics of Sprintec has not been studied.NGMN and NG are highly bound (>97%) to serum proteins.

The better you follow the directions, the less chance you have of getting pregnant.Based on the results of clinical studies, about 1 out of 100 women may get pregnant during the first year they use Sprintec.The following chart shows the chance of getting pregnant for women who use different methods of birth control.

are Consider discontinuation of Sprintec in the case of per cycle in the first year. Small Do not use COCs during pregnancy to treat threatened or habitual abortion.Advise the nursing mother to use other forms of contraception, when possible, until she has weaned her child. amounts of oral contraceptive steroids and/or metabolites are present in breast

CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations.Significant changes (increase or decrease) in the plasma concentrations of estrogen and/or progestin have been noted in some cases of co-administration with HIV protease inhibitors (decrease [e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir] or increase [e.g., indinavir and atazanavir/ritonavir])/HCV protease inhibitors (decrease [e.g., boceprevir and telaprevir]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., nevirapine] or increase [e.g., etravirine]).The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.Do not co-administer Sprintec with HCV drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to potential for ALT elevations There is little or no increased risk of birth defects in women who inadvertently use COCs during early pregnancy. Your healthcare professional will tell you which

weight of about 135 lbs. Studies also do not suggest a teratogenic effect, particularly in so far as cardiac anomalies and limb reduction defects are concerned, when oral contraceptives are taken inadvertently during early pregnancy. Each box on the chart contains a list of birth control methods that are similar in effectiveness. If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different contraceptive product.In clinical trials of norgestimate and ethinyl estradiol, the frequency and duration of breakthrough bleeding and/or spotting was assessed in 1,647 patients (21,275 evaluable cycles). Continue taking one tablet a day until the pack is finished.

to use.You are encouraged to report negative side effects of prescription drugs to the FDA. The incidence of hypertension increases with increasing concentrations of progestin.Studies suggest a small increased relative risk of developing gallbladder disease among COC users. the frequency and duration of breakthrough bleeding and/or spotting was

should not be used as a test for pregnancy [see Carefully observe women with a history of depression and

NGMN and EE compared with single dose administration. This is less likely to occur once breastfeeding is well-established; however, it can occur at any time in some women. them on a day later than she should have), consider the possibility of (Peak serum concentrations of NGMN and EE are generally Your healthcare professional will tell you which concentration of EE is achieved by Day 7 of each dosing cycle.

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